Scientist, In Vivo Electrophysiology

The Neurophysiology group within the Research and Development organization at our Waltham R&D Site is searching for an experienced neurobiologist with a deep passion for understanding neural circuit functions in the normal and diseased brain.  Individuals with extensive in vivo electrophysiology/ physiology experience and interest in connecting circuit- and behavioral-level findings to translational biomarkers are encouraged to apply.  The candidate is expected to perform a wide range of discovery neuroscience activities. These include designing and executing rodent behavioral studies, electroencephalography (EEG), and in vivo single unit recordings in freely behaving rodents to probe the neural circuit basis of psychiatric disorders and evaluate the effects of novel therapeutics.  In addition, collaborate with cross‑functional partners to identify and validate novel drug targets and advance drug discovery programs. Collectively, these efforts directly support the advancement of mechanism‑based therapeutics and the translation of preclinical insights into clinical impact.  

Key Duties:

• Independently design, develop, and implement in vivo protocols and assays 
• Engage in thorough analysis of data collected, generate summaries and interpretations of results, and present summaries within the Neurophysiology group, Neurobiology group, and/or Research Department, and the greater Alkermes community 
• Explore and apply new models, methodologies, and technologies to expand the group’s capabilities and help drive programs forward 
• Contribute to novel target identification and validation strategy across a broad range of CNS 
  disorders

Technical Skills:

• Proficient in vivo electrophysiological/ physiological techniques in freely moving rodents is required
• Proficient in small rodent surgeries (e.g, electrode implants, cannulation, optical fibers)
• Proficient in EEG/LFP signal processing (i.e. FFT, Wavelet analyses), spike-train analysis and/or single unit isolation routines is required
• Significant programming experience (i.e. Matlab, Python, etc…) is required 
• Significant experience with rodent behavioral paradigms is required
• Solid background in systems neuroscience is highly desired
• Experience with optogenetic/chemogenetic techniques in vivo is beneficial

Personal Skills:

• Must work well in a team environment and have excellent interpersonal skills
• Well organized and able to multi-task 
• Outstanding personal initiative with the ability to take the lead, influence, and motivate others
• Strong desire to push the boundaries of the science, champion innovative technologies and approaches, and be flexible to learn and take on new tasks when needed
• Strong communication skills and ability to distill and present complex datasets into meaningful decision-making information

Minimum Education and Experience:

• A Ph.D. in neuroscience, neurobiology, or related discipline, a MS degree with 5+ years of experience, or a BS degree with 10+ years of experience is required
• Experience in a biotechnology/pharmaceutical setting is strongly preferred but not required

The annual base salary for this position ranges from $116,000 - $137,000. In addition, this position is eligible for an annual performance pay bonus.  Exact compensation may vary based on skills, training, knowledge, and experience. Alkermes offers a competitive benefits package.  Additional details can be found on our careers website: www.alkermes.com/careers#working-here 

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Why join Team Alkermes?

Alkermes applies its decades of deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders. A global biopharmaceutical company, headquartered in Ireland with U.S. locations in Massachusetts and Ohio, we seek to make a meaningful difference in the way people manage their diseases. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.

We are proud to have been recognized as an employer of choice by many national organizations. In 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts’ Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine. 

Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any qualified applicant or employee because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other characteristic protected by local, state or federal law.  Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Alkermes is an E-Verify employer.