Senior Clinical Research Associate (Sr. CRA)-Excl. IT Costs

Senior Clinical Research Associate

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development

As a Senior Clinical Research Associate at ICON, you will be responsible for the monitoring and oversight of clinical trial sites, ensuring studies are conducted in accordance with the protocol, ICH‑GCP, and applicable local and international regulatory requirements.
This role sits within ICON Strategic Solutions, embedded with a sponsor partner, offering the opportunity to build strong site relationships while delivering high‑quality clinical research.

What You Will Do:

In this role, you will be responsible for the end‑to‑end monitoring and oversight of investigator sites across the full clinical trial lifecycle.

Key responsibilities include:

• Conduct site qualification, initiation, monitoring, and close‑out visits in line with the Clinical Monitoring Plan
• Maintain full ownership of assigned investigator sites, ensuring effective management through to study close‑out
• Ensure investigator site compliance with study protocols, ICH‑GCP, sponsor SOPs, and regulatory requirements
• Provide initial and ongoing training to site personnel on protocol requirements, procedures, and Good Clinical Practice
• Support study start‑up activities, including feasibility, essential document collection and review, and Ethics Committee submissions
• Identify site‑level risks and issues, and support the implementation of corrective and preventive actions
• Build and maintain effective, collaborative working relationships with investigators, site staff, and cross‑functional study teams

Your Profile:

To succeed in this role, you will bring strong clinical monitoring experience, independence in site management, and a proactive approach to quality and compliance.

Required qualifications and experience:

• A degree in life sciences, nursing, or a related discipline
• Proven experience working as a Clinical Research Associate, with at least 4 years’ independent site monitoring experience in a CRO or pharmaceutical environment
• Strong working knowledge of ICH‑GCP guidelines and applicable local and international regulatory requirements
• Ability to manage multiple investigator sites and priorities independently while meeting tight deadlines
• Willingness to travel up to 60% of the time and possession of a valid driving licence
• Based in Gauteng, South Africa
• Cardiovascular therapeutic area experience is desirable

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements

• A range of health insurance offerings to suit you and your family’s needs.

• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.

• Global Employee Assistance Programme, TELUS Health, offering 24-hour access to a global network of over 80,000 independent specialised professionals who are there to support you and your family’s well-being.

• Life assurance

• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidised travel passes, health assessments, among others.

Visit our careers site to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values.   We’re dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here.

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

Are you a current ICON Employee? Please click here to apply