Senior Research Associate - ADME/DMPK

• Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays

• Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)

• Support development and validation of new ADME assays to expand the group’s scientific capabilities

• Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)

• Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators

• Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable

• Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions

• Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams

• Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics

Requirements

• Master's in Lifescience with 4-5 years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.

• Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles

• Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments

• Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding

• Ability to troubleshoot experimental challenges and apply sound scientific judgment

• Self-driven and capable of managing multiple tasks while working within demanding project timelines

• Strong attention to detail and commitment to maintaining high scientific and data quality standards

• Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams

• Strong communication skills for interacting with internal teams, collaborators, and stakeholders

• Highly organised with the ability to function effectively in a fast-paced research environment

• Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs

• A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h