Scientist, iPSC Differentiation (Hematopoiesis)

Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan.

We’re building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility.

We are hiring a new member of the HSC Therapeutics team who will bring deep expertise in hematopoiesis. In this role, you will focus on process optimization and development to help us create scalable differentiation protocols. 

About you:

You’re eager to learn and approach work with a “can-do” attitude and a hands-on nature. You take pride in working at the highest standard, continuously optimizing research practices for both high speed and accuracy. You value being organized and detail-oriented. Bringing a clear, transparent communication style, you collaborate effectively with specialists of various backgrounds (bench and computational biologist, quality control scientists, operational and logistic specialists). You are adaptable and able to iterate quickly and reprioritize based on a mission > team > self hierarchy. You’re motivated to work on the forefront of science and help us extend healthy lifespan!

In this role you will:

• Adapt differentiation protocol to large-scale production in bioreactors and optimize banking of final product for clinical use.

• Optimize differentiation process for reproducible and predictable cell output.

• Contribute to the full process of producing a high-quality iHSC product out of iPSCs: maintain iPSCs, prepare and change media throughout differentiation, analyze cells using flow cytometry, and formulate iHSCs.

• Transfer differentiation and formulation protocols to the GMP environment.

• Assist in processing mouse tissues and performing flow cytometry to characterize cell function.

• Work collaboratively across Retro teams such as Technical In-Vivo, Computational Biology, Automation, and Quality and Analytics.

• Be part of a rotational weekend work schedule. 

You might thrive in this role if you:

• Have a Bachelor’s or Master’s degree in Biology or a relevant field and 4+ or 6+ years of relevant experience in industry, respectively, or a Ph.D. in Cell Biology, Molecular Biology, or related discipline. 

• Learn quickly and establish and follow protocols precisely. 

• Your deepest expertise is in hematopoiesis. 

• Have 2+ years of experience in differentiating iPSCs into immune cells.

• Enjoy standardizing lab practices and establishing highly reproducible protocols.

• Have 2+ years of experience with cell characterization using flow cytometry.

• Have excellent note-taking skills and take pride in maintaining detailed ELN. 

• Proficient in designing and coordinating projects across multiple parties. 

• Proficient in communicating results of experiments.

It’s a bonus if you:

• Had exposure to the GMP environment and participated in IND filings.

• Have experience with process development and scaling cell therapies in bioreactors.

We take pride in cultivating an environment that fosters collaboration, open communication, and authenticity. We believe that great results are best delivered by a highly creative team working in concert. We are an equal opportunity employer; we do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We are diverse in background and singular in mission.