Sr Scientist, Protein Biochemistry

Product Biochemistry at Regeneron is seeking a highly motived and experienced scientist to join our team. In this exciting role, you will contribute to analytical characterization studies to support the life cycle management of biologics and biotherapeutics, including but not limited to monoclonal antibodies, bispecific antibodies and other modalities. The ideal candidate will have a strong background in analytical characterization to drive innovation in biochemical and biophysical method development, and will foster productive collaboration, act as a subject matter expert/technical resource within cross-functional teams to advance developmental pipeline.

A Typical Day in the Role Might Look Like:

• Independently develop and execute biochemical and biophysical characterization workflows to support the life cycle management of Regeneron commercial programs.
• Build in-depth understanding of degradation profile(s) of biologics and biotherapeutics and its impact on binding and potency.
• Develop, optimize and execute new analytical methods to characterize challenging biologics and biotherapeutics in formulation buffer/condition.
• Develop core expertise in binding affinity and kinetics assays and conduct binding assays using SPR, BLI and other technology platforms.
• Resolve key project challenges by optimally utilizing available analytical techniques, information and expertise.
• Record, analyze, and report data timely and concisely, formulate conclusions and provide project updates internally as well as to cross-functional teams and senior management.

This Role Might Be for You If You:

• Have familiarity with GxP requirements in assay execution, method qualification, instrument maintenance and documentation; concept of method qualification and qualified instruments preferred
• Are hardworking, efficient, flexible, and able to perform key responsibilities in a fast-paced, team environment
• Have the ability and passion for independently learning new methods and software
• Possess excellent written and verbal communication skills and the ability to prepare slides and author reports and manuscripts for internal and external presentations

This role requires BS or MS or PhD in biochemistry, biophysics, chemistry, biology or related field with typically 10+ (BS), 8+ (MS) or 0+ (PhD) years of experience. A proven theoretical and practical understanding of biochemistry and biophysics with the ability to learn and master innovative technologies is required. In-depth experience with various biochemical and biophysical methods, such as SPR, BLI, ELISA, DLS, etc is needed. Deep understanding of protein structure, thermodynamics, and molecular interaction is a plus. Robust analytical knowledge with demonstrated proficiency in chromatographic and capillary electrophoresis techniques is a plus. Direct experience with characterization of monoclonal antibodies in formulation buffer/condition is a plus. Experience in CMC analytical development of monoclonal antibodies or biotherapeutics is a plus. Understanding of host cell proteins and their impact on biologics and biotherapeutics is a plus.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location.  In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/.  For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together.  For that reason, many of Regeneron’s roles are required to be performed on-site.  Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.
 

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions.  For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process.  Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$109,900.00 - $179,300.00